dioscorea japonica nutrition

While there are over 600 species of wild yam, only 12 are edible. Dioscorea tuber mucilage from Taiwanese yams (Dioscorea Japonica Thunb var.) Wild yam may also help reduce irritability, and its anti-inflammatory benefits might offer relief of joint pain that often accompanies menopause. Listed below are few of the known health benefits of wild yam, Wild yam consists of a chemical called dioscoretine, which some people think helps with the regulation of blood sugar levels. Increased expression of COX-2 is commonly observed in lung tumors as well as in many other tumors. DIOSCOREA JAPONICA ROOT EXTRACT and EXTRACT OF DIOSCOREA JAPONICA ROOT. The species is dioecious (individual flowers are either male or female, but only one sex is to be found on any one plant so both male and female plants must be grown if seed is required). (8) Among these, mPGES-1 belongs to the membrane-associated proteins involved in eicosanoid and glutathione metabolism family and is usually up-regulated in accordance with COX-2 induction. Effects of Taiwanese yam (Dioscorea japonica Thunb var. Rheumatoid arthritis is a chronic condition that causes inflammation of the joints. It is in flower from September to October. Furthermore Dioscorea japonica extract suppressed the expression of the anti-apoptotic factor B-cell chronic lymphocytic leukemia/lymphoma 2 and enhanced apoptotic terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling-positive intensity in A549 cells. Powder form of Wild Yam can be added to cream or vaginal ointments. As the name suggests, an early use was to relieve colic in babies. ap<0.01 compared with the control without TPA and DJE and bp<0.01 compared with TPA treatment without DJE. Be sure to consult your child’s pediatrician before giving your child any alternative treatment. Of all cancers, lung cancer has the highest mortality, and the 5-year survival rate is very low. Dioscorea japonica goes under several common names. Corresponding Author. glauca (Muhl. Isolation and hypoglycemic activity of dioscorans A, B, C, D, E, and F; glycans of. It is hardy to zone (UK) 5. Leaves are mostly alternate, though may be whorled or nearly so near the base of the plant, 1 to 5 inches long, ¾ to 5 inches wide, heart-shaped, sharply pointed at the tip, with 7 to 11 deep veins radiating from the base and a hairless stalk up to 6 inches long that may be ridged or narrowly winged, sometimes with a few hairs where the stalk joins the blade. Privacy Policy This is a popular form of wild yam and can be easily added to water, smoothies, or green juices. 5A top panels). Keelung yam exerted pronounced effects in lipid metabolism. Induction of apoptosis by trichostatin A, a histone deacetylase inhibitor, is associated with inhibition of cyclooxygenase-2 activity in human non-small cell lung cancer cells. *p<0.05 compared with treatment with 0 µM diosgenin. Consuming wild yam can give rise to many allergic reactions like rashes or hives in some women. Dioscorea batatas is a PERENNIAL growing to 3 m (9ft) by 1.5 m (5ft). The following primer pairs were used for amplification of COX-2, mPGES-1, B-cell chronic lymphocytic leukemia/lymphoma 2 (Bcl-2) and glyceraldehyde 3-phosphate dehydrogenase (GAPDH); 5'-TGCATTCTTTGCCCAGCACT-3' (COX-2 forward), 5'-AAAGGCGCAGTTTACGCTGT-3' (COX-2 reverse), 5'-TGATCACACCCACAGTTGAGC-3' (mPGES-1 forward), 5'-TGATGATGGCCACCACGTA-3' (mPGES-1 reverse), 5'-TGGATGACTGAGTACCTGAA-3' (Bcl-2 forward), 5'-CCAGGAGAAATCAAACAGAG-3' (Bcl-2 reverse), 5'-CGACATCCCTCCAAAATCAA-3'(GAPDH forward), and 5'-TTCACACCCATGACGAACAT-3' (GAPDH reverse). DJE by 50% ethanol (0–100 µg/ml) was added to A549 cells. However, the effect of diosgenin on COX-2 expression was lower than that of DJE by 50% ethanol (100 µg/ml DJE), which decreased COX-2 expression to 27% (Fig. The protein expression levels of COX-2 and mPGES-1 were analyzed by Western blotting. glabra J.Lloyd ex A.Gray, Dioscorea villosa var. Developmental & Reproductive Toxicity . It contains diastase and amylase enzymes that help to break down starches so they are easily usable. Diosgenin (0.1–10 µM) was added to A549 cells. The methanol:water extract of the Dioscorea dumetorum tuber exerts strong hypoglycemic effects in normal mice.28 Therefore, the lower sucrase activity caused by Keelung yam (D. japonica Thunb var. The cells were cultured in Dulbeco’s modified Eagle’s medium supplemented with 10% fetal bovine serum, 100 U/ml penicillin, and 100 mg/ml streptomycin. Root should not be stored for longer than 1 year, since it is likely to lose its medicinal virtues. Diosgenin found in wild yam was used to make the first birth control pills in the 1960s. Herb: Chinese Yam Latin name: Dioscorea batatas Synonyms: Dioscorea opposita, Dioscorea polystachya Family: Dioscoreaceae (Yam Family) Medicinal use of Chinese Yam: The Chinese yam, called Shan Yao in Chinese herbalism, is a sweet soothing herb that stimulates the stomach and spleen and has a tonic effect on the lungs and kidneys. Dried root of wild yam is used to make a variety of medicinal preparations. Hyperpigmentation is harmless and rather common, but it can be frustrating since it is a skin condition that develops, rather noticeably, as darker patches of skin.(3). Sulforaphane inhibits prostaglandin E. Srinivasan S, Koduru S, Kumar R, Venguswamy G, Kyprianou N, Damodaran C. Diosgenin targets Akt-mediated prosurvival signaling in human breast cancer cells. In lung cancer cells, inhibition of COX-2 by trichostatin A,(25) a histone deacetylase inhibitor, or celecoxib,(26) a NSAID that acts as a selective COX-2 inhibitor, correlates with a decrease in PGE2 production. 2A). Nutrition 2003, 19 (7-8) , 646-651. Female flowers sit on top of winged green fruits, 3-celled seed capsules that are ovoid in shape and about 1″ long; these capsules are strongly 3-angled, Flattened seeds have broad membranous wings, Initially taste starchy, but soon after taste bitter and acrid, Tablet, capsule, tincture, skin cream, herbal tea, powder, doctor prescribed steroids, topical ointments, infusions, Spermatophytina  (spermatophytes, seed plants, phanérogames), Lilianae  (monocots, monocotyledons, monocotyledons). twining vine native to the central southeastern US and found less frequently in the Appalachian region Antiproliferative activity of guava leaf extract via inhibition of prostaglandin endoperoxide H synthase isoforms. Treatment with 100 µg/ml DJE significantly decreased mRNA levels of COX-2 and mPGES-1 to 27% and 46% compared with the control, respectively. E-mail: Received 2014 Feb 14; Accepted 2014 May 14. This can cause pain and stiffness that limits mobility in people with the condition. pseudojaponica Yamamoto) on upper gut function and lipid metabolism in Balb/c mice. The upper surface is hairless and the lower variously hairy, sometimes hairless or glandular. Identity Taxonomic Tree List of Pests Uses List Summary. hirticaulis (Bartlett) R.Knuth, Dioscorea villosa subsp. Wanasundera JPD, Ravindran G. Effects of cooking on the nutrient and antinutrient contents of yam tubers (, Hikino H, Konno C, Takahashi M, et al. Dioscorea or Yam Roots are perennial, herbaceous climbers from open woods throughout the northern and southern hemisphere. The cells were treated with 0–100 µg/ml DJE in dimethyl sulfoxide, 0–10 µM diosgenin (Sigma, St. Louis, MO) in dimethyl sulfoxide or were added only vehicle as a control. the display of certain parts of an article in other eReaders. R.E. The plant is not self-fertile. Dioscorea japonica extract induced the translocation of nuclear factor-κB from the nucleus to the cytosol and inhibited the activity of the cyclooxygenase-2 promoter. *p<0.05 and **p<0.01 compared with the control. Furthermore Dioscorea japonica extract suppressed the expression of the anti-apoptotic factor B-cell chronic lymphocytic leukemia/lymphoma 2 and enhanced apoptotic terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling-positive intensity in A549 cells. Ng SC, Chan FK. – Japanese yam Subordinate Taxa. The relative expression levels were shown against control and were mean ± SD of 5 separate experiments. *p<0.05 compared with treatment with 0 µg/ml extract. Yamamoto K, Wang J, Yamamoto S, Tobe H. Suppression of cyclooxygenase-2 gene transcription by humulon of beer hop extract studied with reference to glucocorticoid. Male flowers are arranged in small clusters of 1-3 along the branches of each panicle. After the treatment for 48 h, the cells were fixed with 4% paraformaldehyde for 10 min and 0.5% ethanol for 2 min. https://www.itis.gov/servlet/SingleRpt/SingleRpt?search_topic=TSN&search_value=43367#null, https://davesgarden.com/guides/pf/go/53538/, https://pfaf.org/user/Plant.aspx?LatinName=Dioscorea+villosa, https://www.botanical.com/botanical/mgmh/y/yam—01.html, https://plants.usda.gov/core/profile?symbol=divi4, http://www.theplantlist.org/tpl1.1/record/kew-241123, https://herbpathy.com/Uses-and-Benefits-of-Dioscorea-Villosa-Cid2195, https://medlineplus.gov/druginfo/natural/970.html, http://www.flowersofindia.net/catalog/slides/Wild%20Yam.html, http://pennstatehershey.adam.com/content.aspx?productId=107&pid=33&gid=000280, https://www.frostburg.edu/fsu/assets/File/ACES/Dioscorea%20villosa%20-%20FINAL(3).pdf, https://en.wikipedia.org/wiki/Dioscorea_villosa. vera Prain & Burkill. TPA (0.1 µM), a COX-2 inducer, increased luciferase activity by approximately 4-fold, and addition of DJE significantly decreased TPA-induced luciferase activity to a level similar to that of the control. Kim DS, Jeon BK, Lee YE, Woo WH, Mun YJ. It is hardy to zone (UK) 8. Food. Traditional uses and benefits of Wild Yam, Wild Yam Recipe for Coughs, Spasms and Nausea. The aim of this study was to explore the novel functional effects of D. japonica on the regulation of the PGE2 synthesis pathway. (24) However, long-term use of NSAIDs can cause life-threatening side effects, including gastrointestinal injury and renal pathology. Since Asian people prefer it a lot, it is still grown in France and sold to the Asia market. hirticaulis (Bartlett) H.E.Ahles, Dioscorea villosa var. COX activity after the treatment without (open column) or with (closed column) DJE (100 µg/ml) was measured. The values are represented as a relative value control cells, Effect of diosgenin on the expression of COX-2 and mPGES-1 in A549 cells. Known to cause headaches, menstrual irregularities & acne. COX activity was analyzed as described previous report. It treats Postmenopausal Vaginal dryness, Premenstrual Syndrome, Breast Enlargement, Menstrual Cramps and Osteoporosis. However, the other physiological effects of D. japonica have not been completely elucidated. glauca (Muhl. (3) COX has 2 isozymes, COX-1 and COX-2. Wild yam is POSSIBLY SAFE when taken by mouth or applied to the skin. (34) In the present study, the effect of diosgenin (0–10 µM) on the expression of COX-2 and mPGES-1 in A549 cells was investigated. Formation of 12-hydroxy-(9Z,13E/Z,15Z)-octadecatrienoic acids from alpha-linolenic acid. mRNA expression of the anti-apoptotic factor Bcl-2 was suppressed after treatment with DJE for 24 h (Fig. laeviuscula Alph.Wood, Dioscorea villosa var. The blooming period occurs during early summer. We are experimenting with display styles that make it easier to read articles in PMC. Wild yam encourages the flow of bile to the duodenum, a part of the small intestine. Traditional medicine practitioners believe that wild yam has anti-inflammatory properties and use it to treat rheumatoid arthritis. Prostaglandin endoperoxide synthase: structure and catalysis. Dioscorea japonica (Japanese yam) Index. PGE2 production was quantified by enzyme immunoassay. Conjunctivitis and certain skin diseases like psoriasis, eczema, etc. Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. Although various medical effects of yam have been demonstrated, there is little current knowledge on the efficacy of Youngyeoja (YYJ; the aerial bulblets of the yam plant), their physiological effects, and their mechanism of action. Roots are anti-inflammatory, antispasmodic, cholagogue, diaphoretic and vasodilator. This plant has no children Legal Status. A proteomic approach to the identification of molecular targets in subsequent apoptosis of HEL cells after diosgenin induced megakaryocytic differentiation. The plant is found growing in thinly wooded bluffs, typical savannas and sandy savannas, woodland borders, typical thickets and sandy thickets, moist sand prairies, power line and railroad clearances in wooded areas, and fence rows, borders of bogs, swamps, marshes, river and lake margins, creek bottoms, rocky soils, moist or dry woods, hammocks, limestone or talus slopes and roadsides. 5B). These are used as contraceptives and in the treatment of various disorders of the genitary organs as well as in a host of other diseases such as asthma and arthritis. 3.0 software (Fujifilm, Tokyo, Japan). The groups Enantiophyllum is made up of the most economically cultivated species such as D. rotundata, D. alata, D. cayenensis, D. opposita and D. japonica. Chemoprevention of azoxymethane/dextran sodium sulfate-induced mouse colon carcinogenesis by freeze-dried yam sanyaku and its constituent diosgenin. D. japonica was pared away the outer skin and was dried under 40°C. Dose-dependent effect of DJE on the expression of COX-2 and mPGES-1 in A549 cells. The cells were counter stained with 4',6-diamidino-2-phenylindole (DAPI). hypoglauca. Dose-dependent effect of DJE on the expression of COX-2 and mPGES-1 in A549 cells. Aluko, E. Monu. This work was funded by JSPS KAKENHI Grant Number 24500948, ASHAHI GROUP FOUNDATION (Tokyo, Japan) and Ryobi Teien Memory Foundation (Okayama, Japan). The values represent mean ± SD of 5 separate experiments. Generating an ePub file may take a long time, please be patient. Hypertension can lead to a number of health complications like stroke, congestive heart failure and even cardiac arrest. Tanioka T, Nakatani Y, Semmyo N, Murakami M, Kudo I. Molecular identification of cytosolic prostaglandin E. Yoshimatsu K, Altorki NK, Golijanin D, et al. Nagaimo is a root vegetable from the family Dioscoreaceae. across and 1/3 inches (8 mm.) long, consisting of 6 whitish green or yellowish green tepals and a large inferior ovary with 6 infertile stamens. 5A). TUNEL positive reactivity was observed with a light microscope (ECLIPSE 80i; Nikon Co., Tokyo, Japan). It may also cause swelling and boil-like eruptions or ulcers in the mouth, lips, throat and tongue. Propagule Powder of Japanese Yam (Dioscorea Japonica) Reduces High‐Fat Diet‐Induced Metabolic Stress in Mice through the Regulation of Hepatic Gene Expression Fumika Shinozaki. It is possible that wild yam might reduce this inflammation and have a positive effect on symptoms, but there is little evidence to support this. A549 cells were treated with DJE by 50% ethanol at 0.1–100 µg/ml concentration, and mRNA expression of COX-2 and mPGES-1 in the cells was analyzed by real-time PCR. However, more research is needed to support this.(7). NSAID-induced gastrointestinal and cardiovascular injury. 5A bottom panels). After converting total RNA to cDNA using High-Capacity cDNA Reverse Transcription Kit (Applied Biosystems, Foster City, CA), quantitative PCR was performed using Eva Green-Comparative Ct method (Bio-Rad). Avoid in patients with cancers of the breast, ovaries, prostate & uterus. It is unclear whether it would have the same effect in humans. After the transfection, A549 cells were treated with 0.1 mM 12-O-tetradecanoylphorbol 13-acetate (TPA) and with or without DJE for 48 h, and the luciferase activity in the culture medium was measured using BioLuxTM Cypridina Luciferase Assay Kit (New England BioLabs Inc., MA). The cycling conditions were 30 s at 95°C, followed by 40 cycles of 95°C for 5 s and 60°C for 10 s. Expression levels of COX-2, mPGES-1 and Bcl-2 mRNAs were normalized to those of GAPDH mRNA. Wild yam roots consist of diosgenin which is extensively used in modern medicine in order to manufacture progesterone and other steroid drugs. Jakobsson PJ, Thorén S, Morgenstern R, Samuelsson B. Some people may also have an allergic reaction to wild yam; it may cause skin irritation when applied as cream. B-cell chronic lymphocytic leukemia/lymphoma 2. Inducible prostaglandin E synthase is overexpressed in non–small cell lung cancer. 8 ounces chopped fresh wild yam root (or 4 ounces of dried). The former is constitutively expressed in various cells, whereas the latter is inducible under pathological condition. Addiction – What Are the Short- and Long-Term Effects of Drug Abuse? Decrease in COX activity (A) and PGE2 production (B) after treatment with DJE. 7). The plant is not self-fertile. It was introduced in Europe in the 19 th century when the potato crop was affected by disease. 5B). pseudojaponica Yamamoto) may exert hypoglycemic effects through reduced sucrase activity. It helps to relieve Hepatic Congestion, Bilious Colic and Gallstones. However, the effect of dioscoretine on blood sugar has only been researched in animals so far. In addition, it was found that the specific antibodies rapidly responded against foreign proteins (or antigens) in the presence of yam mucilage. 2A). It may cause allergic reaction in few as difficult breathing, throat problems, hives and swelling of lips, tongue and face. can be cured with the inclusion of this herb. Root, harvested in September, is used to make a homeopathic remedy. Changes in mRNA expression of Bcl-2 (A) and detection of apoptotic cells (B) after treatment with DJE. Wetland Status. Protein concentration was determined using a BCA protein assay kit (Thermo Scientific Inc., Rockford, IL). (4), (5), (6), Wild yam is believed that it has anti-spasmodic properties, which are substances that reduce muscle spasms. Bulb and roots of wild yams consists of a chemical called diosgenin, which can influence the production of several useful hormones in humans, such as estrogen or dehydroepiandrosterone (DHEA). 1 and 7) post-hoc test at significance level of p<0.05 or 0.01. Yamanoimo have been consumed in Japan since the olden days. mRNA expression of COX-2 (open column) and mPGES-1 (closed column) was measured by real-time PCR, as described, Journal of Clinical Biochemistry and Nutrition. Shaik MS, Chatterjee A, Jackson T, Singh M. Enhancement of antitumor activity of docetaxel by celecoxib in lung tumors. Fatty acid substrate specificities of human prostaglandin-endoperoxide H synthase-1 and -2. Changes in NF-κB localization (A) and COX-2 promoter activity (B) after DJE treatment in A549 cells. Hida T, Yatabe Y, Achiwa H, et al. More Accounts and Images; ARS Germplasm Resources Information Network (DIJA2) Integrated Taxonomic Information System (DIJA2) Wildlife. 6A). Zhou J, Joplin DJ, Cross JV, Templeton DJ. It lowers the Blood Pressure and Blood Cholesterol level. Three spirostanol glycosides from rhizomes of Dioscorea collettii var. American Indians used a tea made from this root, to relieve labor pains. and Dioscorea nipponica Makino, in vitro. It catalyzes 2 reactions, bis-dioxygenation of arachidonic acid to PGG2 and the hydroperoxidation of PGG2 to PGH2. The plant has long, branched, crooked, and woody root, the taste being dull, afterwards acrid. 1). Cyclooxygenase-2 level and culture conditions influence NS398-induced apoptosis and caspase activation in lung cancer cells. Several phytochemicals from other natural products, such as resveratrol,(27) humulon,(28) and chrysin,(29) have been shown to suppress the expression of COX-2. *To whom correspondence should be addressed. Researchers have wondered that taking wild yam may help lower cholesterol levels, although research has shown mixed results. It is usually consumed boiled, steamed, baked or fried. Wild yam has been used for centuries by Native Americans and early Americans for treatment of a variety of ailments. The rhizome of Dioscorea japonica, well-known as “Japanese yam”, is a food and medicinal source known as “San Yak” in Korea. It increases the efficiency of Liver. Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas. After the treatment with or without DJE by 50% ethanol (100 µg/ml) for 48 h, arachidonic acid (10 µM) was added to the culture medium of A549 cells. Diosgenin, an aglycone of the steroidal saponin dioscin that is abundantly found in D. japonica, may be one of the candidate compounds having the functional effects observed in our study. The powders were eluted with 20–80% ethanol (v/v, EtOH), and the extracts were immediately dried-up with nitrogen gas and were completely filling with the gas to protect oxidation. mRNA expression of COX-2 (open column) and mPGES-1 (closed column) was measured by real-time PCR, as described in the Materials and Methods section. 6). You may notice problems with Contents: About Nagaimo (Japanese Yam) Nutritional Value of Nagaimo Handling Nagaimo How to cook Nagaimo? of 5 separate experiments. Diosgenin inhibits Akt signaling and its downstream targets, NF-κB and Bcl-2, in human breast cancer cells. Nutrition Facts Wild yam (jinenjo) Dioscoreaceae japonica is an energizing root vegetable from rugged mountains valued for promoting strength and well-being. We also examined the possibility that D. japonica exerts anti-tumoral effects in lung cancer cells via down-regulation of PGE2 synthesizing enzymes. In contrast, diosgenin did not have a significant effect on the expression of mPGES-1. Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. paniculata (Michx.) 6B). Among the water-soluble extract of D. japonica and DJE by 20, 50, and 80% ethanol, DJE by 50% ethanol was most effective in suppressing the expression of COX-2 and mPGES-1 in A549 cells, whereas the water-soluble extract had little effect (Fig. Yams are perennial herbaceous vines cultivated for the consumption of their starchy tubers in many temperate and tropical regions, especially in Africa, South America and the Caribbean, Asia, and Oceania. Tanikawa N, Ohmiya Y, Ohkubo H, et al. (31) In addition, diosgenin has been shown to induce apoptosis in HepG2 and HEL cells. Diosgenin suppressed COX-2 expression in A549 cells in a dose-dependent manner (0–10 µM), and 10 µM diosgenin reduced COX-2 expression to 46% compared with the control (Fig. Rainsford KD. 2B). D. japonica, a wild yam, is a relative of the Dioscoreaceae family native to Japan. Accordingly, in this study, we focused on the functional effect of Dioscorea japonica (D. japonica) on the regulation of the expression of COX-2 and mPGES-1. Dioscorea japonica, known as East Asian mountain yam, yamaimo, or Japanese mountain yam, is a type of yam native to Japan (including Ryukyu and Bonin Islands), Korea, China, Taiwan, and Assam.. Dioscorea japonica is used for food.Jinenjo, also called the wild yam, is a related variety of Japanese yam that is used as an ingredient in soba noodles. The intracellular localization of transcription factor nuclear factor-κB (NF-κB) was analyzed by fluorescence immunocytochemistry. Scientifically speaking, it’s neither a typical white potato nor a sweet potato. (4) PGES acts downstream of COX and catalyzes the isomerization of PGH2 to PGE2. Isolation and identification of steroidal saponins in Taiwanese yam cultivar (Dioscorea pseudojaponica Yamamoto). (32,33) In a mouse model for colon cancer, diosgenin was shown to decrease gene expression of inflammatory cytokines such as IL-1β and IL-12β and to prevent colon carcinogenesis. Expression of cyclooxygenase-2 in human lung carcinoma. Human non-small cell lung carcinoma cell line A549 (ATCC CCL-185) and human colon carcinoma cell line Caco-2 (ECACC 86010202) were obtained from RIKEN BioResource Center (Tsukuba, Japan). Basic nutritional investigation. The values are represented as a relative value against 0 µg/ml extract-treated cells and represent mean ± SD of 5 separate experiments. already built in. Thus, Dioscorea japonica may contribute to the prevention of prostaglandin E2-mediated pathophysiological responses such as carcinogenesis and inflammation. The values are represented as a relative value against 0 µM diosgenin-treated cells and represent mean ± SD of 5 separate experiments. After incubation for 30 min, PGE2 concentration in the medium was measured by enzyme immunoassay using PGE2 Enzyme Immunoassay Kit (Cayman Chemical Co.) as instructed by the manufacturer. The sections were analyzed using confocal laser scanning light microscopy (CLSM, FV1000, Olympus Co., Tokyo, Japan). Disclaimer, e-mail: [email protected] ex L.C.Beck) R.Knuth, Dioscorea villosa subsp. PubMed:Furostanol saponins from the rhizomes of Dioscorea japonica and their effects on NGF induction. The quest for a food secure and safe world has led to continuous effort toward improvements of global food and health systems. 3). Individual male flowers are about 1/8 inches (3 mm.) Kawakami Y, Nakamura T, Hosokawa T, et al. Identification and characterization of a novel type of membrane-associated prostaglandin E synthase. On the other hand, diosgenin did not have a significant effect on mPGES-1 expression. Arachidonic acid cascade and signal transduction. Thus, it may prove valuable in controlling inflammatory and metabolic processes as well as carcinogenesis. COX-2 and mPGES-1 are constitutively and highly expressed in human lung carcinoma A549 cells. Ha SK, Moon E, Kim SY. Dioscorea japonica extract induced the translocation of nuclear factor-κB from the nucleus to the cytosol and inhibited the activity of the cyclooxygenase-2 promoter. The produced 9- and 13-hydroxyoctadecadienoic acids (HODEs) which cochromatographed on reversed-phase HPLC as a single peak were quantified by the comparison of the area of the peak with that of an internal standard, 15-hydroxyeicosatetraenoic acid (HETE). (16) The lysates were incubated with 100 mM Tris–HCl buffer (pH 7.4) containing 25 mM linoleic acid, and the products were analyzed by reversed-phase HPLC using a COSMOSIL 5C18-MS-II column (5 mm particle, 4.6 × 250 mm, Nacalai Tesque, Kyoto, Japan) with a solvent system of methanol/water/acetic acid (80:20:0.01, v/v). Scale bar indicates 20 µm. The final concentration of DMSO was 0.1% in the medium for control cells and DJE-treated cells. PGE2 released in the culture medium of A549 cells was quantified by enzyme immunoassay. 2014 Nov; 55(3): 162–167. Wild yam’s dried root can be brewed into a medicinal infusion for relieving premenstrual syndrome (PMS) and menopause symptoms. COX-2 promoter assay was carried out as described previously. mRNA expression of the anti-apoptotic factor Bcl-2 were measured by real-time PCR (A). © 2020 Healthbenefitstimes. Yam is the common name for some plant species in the genus Dioscorea (family Dioscoreaceae) that form edible tubers. glabrifolia (Bartlett) W.Stone, Dioscorea villosa var. 4B). Prostaglandins Leukot Essent Fatty Acids. Research Article. Of soil types, including light, medium, and the lower variously hairy, sometimes hairless glandular... Reactions like rashes or hives in some pathological conditions, the effect of diosgenin the! Americans and early Americans for treatment of arthritis, irritable bowel syndrome, gastritis, gall bladder complaints, menstruation... Been found out that wild yam may help to break down starches so they easily. Mpges-1 ( closed column ) DJE ( 100 µg/ml ) was added to A549 cells ) 8 researched dioscorea japonica nutrition so! Yak” in Korea topically on skin to treat hot flashes antispasmodic, cholagogue, and... Reactivity was observed with a light microscope ( ECLIPSE 80i ; Nikon Co., Tokyo Japan. Boil-Like eruptions or ulcers in the body, which could have certain medical benefits the identification natural... Steroid drugs September, is a food and health systems Hepatic Congestion, bilious colic and.... Significantly decreased Bcl-2 mrna levels to 18 % cells via down-regulation of PGE2 from arachidonic acid to PGH2 linoleic! That form edible tubers problems like labored breathing or shortness of breath and characterization of a variety of.. Breast tissue Pressure and blood cholesterol level leading Ingredients in most breast Enhancement supplements/creams since it unclear. Asian people prefer it a lot, it is hardy to zone ( UK ).. Only been researched in animals so far identification of molecular targets in subsequent apoptosis of HEL cells after induced. Information System ( DIJA2 ) Wildlife even cardiac arrest and allow it simmer 20... Swings of menopause and decrease heavy bleeding or unpredictable spotting during peri-menopause that it. Was decreased to 47 % by 10 µM diosgenin ( 0.1–10 µM ) added! And HEL cells mouse colon carcinogenesis by freeze-dried yam sanyaku and its targets! Of guava leaf extract via inhibition of prostaglandin endoperoxide H synthases ( cyclooxygenases ) -1 and.... A tea made from this root, the expression of COX-2 and are. ( closed column ) and prostaglandin E synthase is overexpressed in non–small cell lung cancer cells whereas... And DJE-treated cells Inc., Rockford, IL ) ft. tall cause vomiting and other side effects such as and! ), 646-651 ( 24 ) however, the isozymes cyclooxygenase-2 and microsomal E... Bleeding or unpredictable spotting during peri-menopause Niimi, Japan ) kit ( Roche ) p 0.05. Are experimenting with display styles that make it easier to read articles in PMC that ovoid... Tumors as well as in many other tumors BCA protein assay kit ( Roche ) factor-κB ( NF-κB was. A long time, please be patient the activity of dioscorans a, Jackson T, Y. Mpges-1 after treatment with 0 µM diosgenin-treated cells and represent mean ± SD of 5 experiments., Vainio H, Tanioka T, Abiko Y, Okayama m, Mizoguchi I, Takuma, Nakamura,! And very showy, dense foliage on long vines medicinal preparations were counter stained with 4',6-diamidino-2-phenylindole ( )! A new approach to the cytosol and inhibited the activity of guava extract... Gastrointestinal toxicity and cardiovascular risk that limits mobility in people with diabetes and requires soil... Homeopathic remedy is a relative value control cells and represent mean ± SD of 5 separate experiments be.. Survival rate is very low manner ( Fig the genus Dioscorea ( Dioscoreaceae... Counterstain DAPI in control A549 cells ( B ) after treatment with DJE Student s! Has the highest mortality, and the lower variously hairy, sometimes or! Colic in babies, Yao X, Kobayashi H, Tanioka T, Ohta T Heese... Anti-Spasmodic properties, which have several `` ease of reading '' features already built in easily usable Suzuki. Novel drug target knotty, woody, cylindrical tubers which are substances that muscle! Of joint pain that often accompanies menopause hardy to zone ( UK ) 5 are by! And PGE2 production ( B ) been reported to cause side effects such as gastrointestinal toxicity and cardiovascular risk,... Are highly essential were detected by tunel method, as described in the Materials Methods. €œSan Yak” in Korea root can be used to ease the pain of childbirth in. Indians used a tea, is used to make the first birth control pills in the,... Heat and allow it simmer for 20 to 30 minutes made from wild yam ’ s dried root, isozymes! E2-Mediated pathophysiological responses, including light, medium, and the 5-year survival rate is very.. Metabolic processes as well as carcinogenesis factor-κB ( NF-κB ) was measured real-time! Arachidonic acid to PGG2 and the hydroperoxidation of PGG2 to PGH2 people with high cholesterol ( PMS.!, since it is likely to lose its medicinal virtues antiproliferative activity of the leading Ingredients most. Individual male flowers about 4-12 inches long develop from the nucleus to the prevention of prostaglandin E and. Of kidney stones catalyzes 2 reactions, bis-dioxygenation of arachidonic acid by enzymes... Swelling and boil-like eruptions or ulcers in the iBooks reader and medicinal source as... Of 5 separate experiments small intestine that causes inflammation of the roots of Dioscorea japonica is a PERENNIAL CLIMBER to... Is weak at this time parts of an article in other eReaders s! And requires moist soil ) and prostaglandin E synthase from bovine heart scanning light microscopy ( CLSM,,. To Japan and assists in the treatment of a variety of ailments increase in clots... Are edible japonica was obtained from Autoraimu Yoshio Ltd. ( Niimi, Japan ) to.! Nutrition 2003, Pages 646-651 to support this. ( 7 ) a, Vainio,... Of Pests uses List Summary of antitumor activity of the anti-apoptotic factor Bcl-2 measured... Freeze-Dried yam sanyaku and its constituent diosgenin take a long time, please be patient a reporter was! Was observed with a light microscope ( ECLIPSE 80i ; Nikon Co., Tokyo Japan... ( 0–100 µg/ml ) was measured using real-time PCR for constructing a linear vector site-specific... Use of NSAIDs can cause vomiting and other side effects, including gastrointestinal and..., although research has shown mixed results 12 are edible is needed to determine whether wild yam aids! E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a novel. Of wild yam is the common name for some plant species in culture., excretory and nervous systems for reducing cramps and Osteoporosis reported to cause headaches Menstrual! Support our results that diosgenin may have suppressive effects on the expression of and! Observed in lung cancer cells, Achiwa H, et al — although fats in the progesterone! Synthase isoforms of human prostaglandin E, and the 5-year survival rate is very.! Treats Postmenopausal vaginal dryness dioscorea japonica nutrition premenstrual syndrome, gastritis, gall bladder complaints, painful menstruation etc DS Jeon... 30 minutes moist soil, dense foliage on long vines the signal transduction pathway mediating COX-2 induction hot. Value of Nagaimo Handling Nagaimo How to cook Nagaimo nuclear factor-κB from the nucleus to the skin some. 24 H ( Fig grow in the culture medium of A549 cells Ltd. dioscorea japonica nutrition Niimi, Japan.!, crooked, and woody root, harvested in September, is good for morning sickness by Western.... Dioecious, producing vines with either all male flowers or all female flowers are about inch... Herb by the wind lose its medicinal virtues it treats Postmenopausal vaginal,... Cancer in government, industry or academic studies or assessments, baked or fried or shortness of breath,. Against 0 µg/ml extract-treated cells and represent mean ± SD of 3 separate experiments vines. Reduced sucrase activity female vines, panicles of numerous male flowers are arranged in small clusters of 1-3 along branches. H synthase isoforms and bring to boil with COX-2 promoter activity ( a ) )! Concentration was determined using a BCA protein assay kit ( Roche ) to treat hot flashes manner, its. Distributed by the enzymes cyclooxygenase and prostaglandin E synthase site-specific DNA methylation uses. Of kidney stones of diosgenin on the regulation of the digestive, excretory and nervous systems saponins! S T test ( Fig effects on the expression of COX-2 and mPGES-1 in cells. Balancing female hormones and assists in the medium for control cells and DJE-treated cells freeze-dried yam sanyaku and its targets... With DJE for dioscorea japonica nutrition H ( Fig led to continuous effort toward improvements of global food and medicinal known. Flowers or all female flowers are about 1/8 inches ( 3 ): 162–167 Pressure and cholesterol. Promoting strength and well-being 6A ) or with ( closed column ) and detection apoptotic... Anti-Inflammatory, antispasmodic, cholagogue, diaphoretic and vasodilator rhizomes of Dioscorea and! Integrated Taxonomic Information System ( DIJA2 ) Integrated Taxonomic Information System ( DIJA2 ) Wildlife use. May notice problems with the help of the digestive, excretory and nervous.. Ethanol significantly decreased Bcl-2 mrna levels to 18 % tunel positive reactivity was observed with a microscope... As in many other tumors the metabolism of arachidonic acid by the wind rheumatoid arthritis and for increasing Energy colic! Root extract is an extract of Dioscorea japonica Thunb var. ), 646-651 through! ( Dioscorea japonica Thunb var. body, which have several `` ease of reading '' features already in..., long-term use of NSAIDs can cause life-threatening side effects such as carcinogenesis and inflammation the to! Are some reports that support our results that diosgenin may have suppressive effects on the other hand diosgenin! Steroidal saponin constituent and is found more abundantly in a dose-dependent manner ( Fig Dioscoreaceae family native to Japan considered. Potato crop was affected by disease to prostaglandin E2 overproduction and lipid metabolism in BALB/c mice BK, Lee,!

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